SSL persistence is a type of persistence that tracks SSL sessions using the SSL session ID, and it is a property of each individual pool. Using SSL persistence can be particularly important if your clients typically have translated IP addresses or dynamic IP addresses, such as those that Internet service providers typically assign. Even when the clients IP address changes, Local Traffic Manager still recognizes the session as being persistent based on the session ID.
You might want to use SSL persistence and source address affinity persistence together. In situations where an SSL session ID times out, or where a returning client does not provide a session ID, you might want Local Traffic Manager to direct the client to the original node based on the clients IP address. As long as the clients simple persistence record has not timed out, Local Traffic Manager can successfully return the client to the appropriate node.

SSL persistence profile